Clinical trialNCT01736553CompletedObservational

Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development

SponsorOhio State UniversityEnrollment53Spinal Muscular Atrophy (SMA)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Spinal muscular atrophy (SMA) is the leading genetic cause of death of infants. Strong preclinical evidence suggests that effective therapy must be delivered as early as possible to prevent progression of the disease. The primary study objective will be to identify prognostic and surrogate biomarkers of disease progression that will facilitate the execution of therapeutic SMA clinical trials in infants.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Stephen J Kolb, MD PhD
Ohio State University
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California - Davis
Davis, California, United States
University of California - Los Angeles
Los Angeles, California, United States
Children'S Hospital Colorado
Aurora, Colorado, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Ann & Robert H. Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
Boston Children'S Hospital
Boston, Massachusetts, United States
Children'S Mercy Hospital
Kansas City, Missouri, United States
Washington University in St. Louis School of Medicine
St Louis, Missouri, United States
Columbia University Medical Center
New York, New York, United States
State University of New York Upstate Medical Center
Syracuse, New York, United States
Nationwide Children'S Hospital
Columbus, Ohio, United States
Doernbecher Children'S Hospital
Portland, Oregon, United States
Vanderbilt University
Nashville, Tennessee, United States
Children'S Medical Center of Dallas
Dallas, Texas, United States
University of Utah Health Sciences Center
Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Dec 2012
Primary completion: 30 Sept 2015
Completion: 30 Sept 2015
Last update posted: 4 May 2018
Registered enrollment: 53
Registry id: NCT01736553

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.