Clinical trialNCT01801423CompletedInterventional

Sickle Cell Disease - Stroke Prevention in Nigeria Trial

SponsorVanderbilt University Medical CenterEnrollment29Sickle Cell AnemiaSickle Cell DiseaseStroke

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Given large absolute numbers of individuals with sickle cell disease in Nigeria, hydroxyurea therapy for all individuals with sickle cell disease may not be initially feasible; however, a targeted strategy of hydroxyurea use for primary prevention of strokes is an alternative to the standard therapy (observation) for high-risk individuals. The investigators propose a feasibility study, Sickle Cell Disease - Stroke Prevention in Nigeria (SPIN) Trial, to determine whether hydroxyurea can be used for primary prevention of strokes in Nigerian children with sickle cell anemia.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Lori Jordan, MD, PhD
Vanderbilt University
Principal Investigator
clinicaltrials.gov ↗
Michael R. DeBaun, MD, MPH
Vanderbilt University
Principal Investigator
clinicaltrials.gov ↗
Muktar Aliyu, MBBS, MPH, DrPH
Vanderbilt University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Nigeria

Aminu Kano Teaching Hospital
Kano, Nigeria

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Hydroxyurea →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Apr 2013
Primary completion: 31 Jan 2019
Completion: 31 Jan 2019
Last update posted: 3 Aug 2020
Registered enrollment: 29
Registry id: NCT01801423

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.