Clinical trialNCT01805999CompletedInterventional

Ispaghula and Colonic Water Content

SponsorUniversity of NottinghamEnrollment15Healthy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Chronic constipation is a phenomenon which affects nearly 20% of the population worldwide. Bulking agents such as ispaghula are used as treatments, but only half of the patients are satisfied with the treatment. This highlights a need for better treatment options, which requires a deeper understanding of the gastrointestinal fate of the products. The GI MRI Research group at the University of Nottingham has been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the gastrointestinal tract. In collaboration with Ironwood Pharmaceuticals, the investigators now want to understand the gastrointestinal fate of an ispaghula treatment, and also to improve the understanding of MRI parameters when they are applied to the colon.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Caroline Hoad, PhD
University of Nottingham
Principal Investigator
clinicaltrials.gov ↗
Ching Lam, MB BCh
University of Nottingham
Principal Investigator
clinicaltrials.gov ↗
Giles Major, MB BChir
University of Nottiingham
Principal Investigator
clinicaltrials.gov ↗
Jeffrey Johnston, MD, FACP
Ironwood Pharmaceuticals, Inc.
Study Director
clinicaltrials.gov ↗
Kathryn Murray, PhD
University of Nottingham
Principal Investigator
clinicaltrials.gov ↗
Luca Marciani, Laurea, PhD
University of Nottingham
Principal Investigator
clinicaltrials.gov ↗
Penny Gowland, PhD
University of Nottingham
Principal Investigator
clinicaltrials.gov ↗
Robin Spiller, MD, FRCP
University of Nottingham
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United Kingdom

Ndd Bru and Sir Peter Mansfield Magnetic Resonance Centre
Nottingham, Nottinghamshire, United Kingdom

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2013
Primary completion: 31 Oct 2013
Completion: 31 Mar 2016
Last update posted: 23 Feb 2017
Registered enrollment: 15
Registry id: NCT01805999

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.