Phase 2A Study of GM 608 in Mild to Moderate Parkinson Disease

GM608 is an endogenous human embryonic stage neural regulatory and signaling peptide that controls the development, monitoring and correction of the human nervous system. The study drug is an oligopeptide with a sequence identical to one of the active sites of human Motoneuronotrophic Factor and is manufactured by solid phase synthesis. Preclinical research indicates it to be a neuro-protective agent in animal models of PD, other neuro-degenerative diseases and stroke. This trial is designed to test proof of principle, i.e. determine if a 2-week treatment with this agent can restore the non-functioning nigral dopaminergic neurons in PD over a 3 month period, during which the placebo-treated arm is expected to have little or no worsening of the total UPDRS (Unified Parkinson's Disease Rating Scale)score compared to baseline. Study Objectives are: 1. To compare the safety and tolerability of GM608 with placebo in a population of patients with early PD. 2. To field test the study procedures for feasibility and efficiency 3. To determine if there is any hint that injections of GM608 might slow the rate of clinical worsening of PD.