Clinical trialNCT01892969CompletedObservational

Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial (CAF-PINT)

SponsorUniversity of California, San FranciscoEnrollment304Heart FailureRespiratory Failure

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Project Summary We propose an ancillary study to The Heart and Lung Failure Pediatric Insulin Titration trial (HALF PINT), which is investigating the impact of normalizing blood glucose using insulin infusions on clinical outcomes among children with hyperglycemia and heart and lung failure. In this ancillary study, we will measure plasma levels of inflammatory, coagulation, and fibrinolysis proteins and genotype DNA for polymorphisms among patients enrolled in the HALF PINT trial. The results from this ancillary study will help us to understand potential mechanisms through which normalizing blood glucose provides benefit, which may lead to development of new therapeutic strategies in critically ill children

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Anil Sapru, MD,MAS
University of California, Los Angeles
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

25 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital of Los Angeles
Los Angeles, California, United States
Mattel Children'S Hospital (ucla)
Los Angeles, California, United States
Children'S Hospital and Research Center of Oakland
Oakland, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Children'S Hospital Colorado - Denver
Aurora, Colorado, United States
Yale - New Haven Children'S Hospital
New Haven, Connecticut, United States
Nemours/alfred I. Dupont Hospital for Children
Wilmington, Delaware, United States
Children'S Healthcare of Atlanta (emory)
Atlanta, Georgia, United States
Ann & Robert H. Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
University of Chicago Medicine Comer Children'S Hospital
Chicago, Illinois, United States
Indiana University Riley Hospital for Children
Indianapolis, Indiana, United States
University of Louisville Children'S Hospital
Louisville, Kentucky, United States
Children'S Hospital of Boston
Boston, Massachusetts, United States
C.S. Mott Children'S Hospital - Michigan
Ann Arbor, Michigan, United States
St. Louis Children'S Hospital
St Louis, Missouri, United States
Dartmouth Hitchcock Medical Center
Manchester, New Hampshire, United States
Women and Children'S Hospital of Buffalo
Buffalo, New York, United States
Cohen Children'S Medical Center of Ny/ North Shore Lij
New Hyde Park, New York, United States
Maria Fareri Children'S Hospital at Westchester Medical Center
Valhalla, New York, United States
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Pennstate Hershey Medical Center
Hershey, Pennsylvania, United States
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Children'S Medical Center Dallas
Dallas, Texas, United States
Medical City Children'S Dallas
Dallas, Texas, United States
Primary Children'S Medical Center
Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 2012
Primary completion: 30 Sept 2016
Completion: 30 Sept 2016
Last update posted: 31 Jul 2020
Registered enrollment: 304
Registry id: NCT01892969

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.