Clinical trialNCT01955616TerminatedPhase 2Interventional

A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation

SponsorMotus Therapeutics, Inc.Enrollment18Parkinson's Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study, called MOVE-PD, is to investigate how individuals with Parkinson's disease (PD) and chronic constipation (CC) respond to RM-131 as compared to placebo. The study will look at how well RM-131 affects the frequency of spontaneous bowel movements over a 14-day period. The study will also evaluate the safety and tolerability of the study drug and evaluate whether the study drug relieves the uncomfortable GI symptoms related to chronic constipation in patients who are unsatisfied with other therapies they have tried for constipation.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Ronald Pfeiffer, MD
Parkinson's Study Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Southern California
Los Angeles, California, United States
Colorado Neurological Institute
Englewood, Colorado, United States
University of Florida Ctr for Movement Disorders & Neurorestoration
Gainesville, Florida, United States
Emory University, Wesley Woods Health Center
Atlanta, Georgia, United States
Georgia Regents University
Augusta, Georgia, United States
University of Iowa Hospitals, Movement Disorders Div, Dept of Neurology
Iowa City, Iowa, United States
Michigan State University
East Lansing, Michigan, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States
Atlantic Neuroscience
Summit, New Jersey, United States
University of Rochester
Rochester, New York, United States
University of Toledo Medical Center
Toledo, Ohio, United States
Movement Disorders Program & the Parkinson'S Center of Oregon
Portland, Oregon, United States
University of Pennsylvania, Penn Neurological Institute
Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboRM-131

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2013
Primary completion: 31 May 2015
Completion: 30 Sept 2015
Last update posted: 23 Sept 2016
Registered enrollment: 18
Registry id: NCT01955616

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.