Clinical trialNCT01969058CompletedPhase 2Interventional

Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery

SponsorAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsEnrollment76HIV-1 Infection

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II study was done in HIV-infected participants on antiretroviral therapy to evaluate the effects of isotretinoin (a drug that is approved for use in the treatment of severe acne) on the immune system. The immune system helps the body fight infections. When the immune system is not working well, one may be at greater risk for diseases that are common in aging, like heart disease, weaker bones, and kidney disease.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Douglas Kwon, MD, PhD
Massachusetts General Hospital
Study Chair
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Nina Lin, MD
Harvard Medical School (HMS and HSDM)
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

5401 Puerto Rico Aids Clinical Trials Unit Crs
San Juan, Puerto Rico

United States

31788 Alabama Crs
Birmingham, Alabama, United States
601 University of California, Los Angeles Care Center Crs
Los Angeles, California, United States
801 University of California, San Francisco Hiv/aids Crs
San Francisco, California, United States
101 Massachusetts General Hospital (mgh) Crs
Boston, Massachusetts, United States
107 Brigham and Women'S Hosp. Actg Crs
Boston, Massachusetts, United States
2101 Washington University Therapeutics (wt) Crs
St Louis, Missouri, United States
31786 New Jersey Medical School Clinical Research Center Crs
Newark, New Jersey, United States
31787 University of Rochester Adult Hiv Therapeutic Strategies Network Crs
Rochester, New York, United States
3201 Chapel Hill Crs
Chapel Hill, North Carolina, United States
3203 Greensboro Crs
Greensboro, North Carolina, United States
2401 Cincinnati Crs
Cincinnati, Ohio, United States
2951 the Miriam Hospital (tmh) Actg Crs
Providence, Rhode Island, United States
3652 Vanderbilt Therapeutics (vt) Crs
Nashville, Tennessee, United States
31473 Houston Aids Research Team (hart) Crs
Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Isotretinoin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 2 Jul 2014
Primary completion: 31 Aug 2016
Completion: 30 Nov 2016
Last update posted: 15 Oct 2024
Registered enrollment: 76
Registry id: NCT01969058

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Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.