Clinical trialNCT01993810Active, not recruitingPhase 3Interventional

Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer

SponsorRadiation Therapy Oncology GroupEnrollment330Stage II Non-Small Cell Lung Cancer AJCC v7Stage IIA Non-Small Cell Lung Carcinoma AJCC v7Stage IIB Non-Small Cell Lung Carcinoma AJCC v7Stage III Non-Small Cell Lung Cancer AJCC v7Stage IIIA Non-Small Cell Lung Cancer AJCC v7Stage IIIB Non-Small Cell Lung Cancer AJCC v7

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase III trial studies proton chemoradiotherapy to see how well it works compared to photon chemoradiotherapy in treating patients with stage II-IIIB non-small cell lung cancer that cannot be removed by surgery. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor, such as photon or proton beam radiation therapy, may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as paclitaxel, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether proton chemoradiotherapy is more effective than photon chemoradiotherapy in treating non-small cell lung cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Zhongxing Liao
NRG Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

30 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Florida Health Science Center - Jacksonville
Jacksonville, Florida, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States
Maryland Proton Treatment Center
Baltimore, Maryland, United States
University of Maryland/greenebaum Cancer Center
Baltimore, Maryland, United States
Upper Chesapeake Medical Center
Bel Air, Maryland, United States
Central Maryland Radiation Oncology in Howard County
Columbia, Maryland, United States
Tate Cancer Center
Glen Burnie, Maryland, United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States
Mass General/north Shore Cancer Center
Danvers, Massachusetts, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States
Procure Proton Therapy Center-Somerset
Somerset, New Jersey, United States
Memorial Sloan Kettering Commack
Commack, New York, United States
Memorial Sloan Kettering Westchester
Harrison, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Memorial Sloan Kettering Rockville Centre
Rockville Centre, New York, United States
Memorial Sloan Kettering Sleepy Hollow
Sleepy Hollow, New York, United States
University of Cincinnati Medical Center
Cincinnati, Ohio, United States
West Chester Hospital
West Chester, Ohio, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
University of Pennsylvania/abramson Cancer Center
Philadelphia, Pennsylvania, United States
Tennessee Cancer Specialists-Dowell Springs
Knoxville, Tennessee, United States
M D Anderson Cancer Center
Houston, Texas, United States
Md Anderson Regional Care Center-Katy
Houston, Texas, United States
Md Anderson Regional Care Center-Bay Area
Nassau Bay, Texas, United States
Md Anderson Regional Care Center-Sugar Land
Sugar Land, Texas, United States
Md Anderson Regional Care Center-the Woodlands
The Woodlands, Texas, United States
Procure Proton Therapy Center-Seattle
Seattle, Washington, United States
University of Washington Medical Center
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Cisplatin →Durvalumab →Etoposide →Paclitaxel →Pemetrexed →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Jan 2014
Primary completion: 30 Nov 2028
Completion: 30 Nov 2028
Last update posted: 8 Jun 2026
Registered enrollment: 330
Registry id: NCT01993810

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.