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Clinical trialNCT02047474CompletedPhase 2Interventional

Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer

SponsorYale UniversityEnrollment46Acinar Cell Adenocarcinoma of the PancreasDuct Cell Adenocarcinoma of the PancreasStage I Pancreatic CancerStage IIA Pancreatic CancerStage IIB Pancreatic Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies how well combination chemotherapy before and after surgery works in treating patients with localized pancreatic cancer. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving these treatments after surgery may kill any tumor cells that remain after surgery.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Smilow Cancer Hospital at Fairfield

    Fairfield, Connecticut, United States

  • Smilow Cancer Hospital at Guilford

    Guilford, Connecticut, United States

  • Smilow Cancer Hospital at St. Francis Hospital

    Hartford, Connecticut, United States

  • Yale University

    New Haven, Connecticut, United States

  • Smilow Cancer Hospital at North Haven

    North Haven, Connecticut, United States

  • Smilow Cancer Hospital at Orange

    Orange, Connecticut, United States

  • Smilow Cancer Hospital at Torrington

    Torrington, Connecticut, United States

  • Smilow Cancer Hospital at Trumbull

    Trumbull, Connecticut, United States

  • Smilow Cancer Hospital at Waterbury

    Waterbury, Connecticut, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

FluorouracilIrinotecanLeucovorinOxaliplatin
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
25 Mar 2014
Primary completion
16 Aug 2022
Completion
14 Jan 2024
Last update posted
6 Mar 2026
Registered enrollment
46
Registry id
NCT02047474
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.