Clinical trialNCT02103660CompletedPhase 4Interventional

Clinical Trial on the Effects of Progestin-based Contraception in the Genital Tract of HIV-infected and Uninfected Women

SponsorCenters for Disease Control and PreventionEnrollment131ContraceptionHIV

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine the acceptability of randomization to contraceptive options and estimate the effect of progestin contraception on HIV genital shedding and inflammatory/immune perturbations in women who may or may not be on antiretroviral therapy, as well as in HIV-uninfected women controls. It is hypothesized that progestin-containing contraception will lead to inflammatory changes that may affect the local immune activity, influencing HIV acquisition or transmissibility risk.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Athena P Kourtis, MD, PhD, MPH
Centers for Disease Control and Prevention
Study Chair
clinicaltrials.gov ↗
Jennifer Tang, MD, MSCR
University of North Carolina
Study Chair
clinicaltrials.gov ↗
Lameck Chinula, MD
UNC-Project Lilongwe
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Malawi

Unc-Project Lilongwe
Lilongwe, Malawi

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Depo-Medroxyprogesterone AcetateProgestin Contraceptive

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Apr 2014
Primary completion: 31 Mar 2017
Completion: 31 Mar 2017
Last update posted: 19 Mar 2018
Registered enrollment: 131
Registry id: NCT02103660

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.