Clinical trialNCT02118831CompletedPhase 1/PHASE2Interventional

Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF

SponsorCalifornia Retina ConsultantsEnrollment56Age-related Macular DegenerationDiabetic Macular EdemaRetinal Vein Occlusion

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Comparable data for bevacizumab and aflibercept are lacking, as are studies comparing the systemic levels of ranibizumab, bevacizumab, and aflibercept and their relative effects on circulating vascular endothelial growth factor. In the present prospective study, the investigators evaluated serum drug levels and plasma free vascular endothelial growth factor (VEGF) levels in patients with neovascular age-related macular degeneration following intravitreal injections of ranibizumab, bevacizumab and aflibercept.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Melvin D Rabena, BS
California Retina Consultants
Study Director
clinicaltrials.gov ↗
Robert L Avery, MD
California Retina Consultants
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

No facility list is in our current data snapshot for this study. The registry record on ClinicalTrials.gov ↗ carries any published locations. Why? →

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AfliberceptBevacizumabBlood Sample CollectionRanibizumab

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2012
Primary completion: 28 Feb 2014
Completion: 30 Apr 2014
Last update posted: 19 May 2016
Registered enrollment: 56
Registry id: NCT02118831

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.