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Clinical trialNCT02120157CompletedPhase 2Interventional

Myeloablative Haploidentical BMT With Post-transplant Cyclophosphamide for Pediatric Patients With Hematologic Malignancies

SponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsEnrollment35Graft SurvivalHLA-mismatched Bone Marrow TransplantationMyeloablative ConditioningTransplantation, Bone Marrow
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi-institutional phase II haploidentical T cell replete bone marrow transplant (BMT) study in children with high-risk leukemia. The myeloablative conditioning regimen prescribed will be Total body irradiation (TBI)-based for lymphoid leukemia and busulfan-based for myeloid leukemia. Our goal is to establish an easily exportable, inexpensive platform for haplotransplantation that has a safety profile equivalent to matched related and unrelated BMTs. The primary objective will be to estimate the incidence of 6-month non-relapse mortality (NRM), hypothesizing that NRM is \< 18%.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • British Columbia Children'S Hospital

    Vancouver, British Columbia, Canada

  • Hospital for Sick Children

    Toronto, Ontario, Canada

United States
  • Children'S Hospital of Colorado

    Aurora, Colorado, United States

  • Nemours Alfred I. Dupont Hospital for Children

    Wilmington, Delaware, United States

  • All Children'S Hospital Johns Hopkins Medicine

    St. Petersburg, Florida, United States

  • Johns Hopkins Hospital

    Baltimore, Maryland, United States

  • Washington University in St. Louis

    St Louis, Missouri, United States

  • Levine Cancer Center

    Charlotte, North Carolina, United States

  • Medical University of South Carolina

    Charleston, South Carolina, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Busulfan →Cyclophosphamide →Mycophenolate mofetil →Tacrolimus →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
2 Jul 2015
Primary completion
15 Jun 2018
Completion
1 Oct 2020
Last update posted
26 Nov 2021
Registered enrollment
35
Registry id
NCT02120157
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.