Clinical trialNCT02149329CompletedPhase 4Interventional

Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO

SponsorAmsterdam UMC, location VUmcEnrollment276Febrile NeutropeniaHematological Malignancy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

A multicenter open-label non-inferiority randomized clinical trial comparing the safety (non-inferiority) of short antibiotic treatment (72 hours) with an anti-pseudomonal carbapenem with regard to treatment failure in comparison with extended treatment (at least 9 days) of high-risk febrile neutropenia in hematology patients receiving standard antimicrobial prophylaxis.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jeroen JWM Janssen, MD, PhD
Amsterdam UMC, location VUmc
Principal Investigator
clinicaltrials.gov ↗
Mark MH Kramer, Prof., MD
Amsterdam UMC, location VUmc
Study Chair
clinicaltrials.gov ↗
Michiel A van Agtmael, MD, PhD
Amsterdam UMC, location VUmc
Principal Investigator
clinicaltrials.gov ↗
Sonja Zweegman, Prof.,MD
Amsterdam UMC, location VUmc
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Netherlands

Vu University Medical Center
Amsterdam, Netherlands
Haga Ziekenhuis
The Hague, Netherlands

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Discontinuation of imipenem-cilastatin or meropenem

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Dec 2014
Primary completion: 5 Aug 2019
Completion: 5 Aug 2019
Last update posted: 25 Sept 2019
Registered enrollment: 276
Registry id: NCT02149329

Cross-registrations

EU-CTR / CTIS (EudraCT)2014-001546-25

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.