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Clinical trialNCT02248636CompletedPhase 2/PHASE3Interventional

Cholinesterase Inhibitor Discontinuation

SponsorVA Office of Research and DevelopmentEnrollment72Dementia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study tries to determine if stopping certain medications that are used to treat dementia will cause worsening from the patient and family perspective. All of the participants will take pills that look identical, and that may contain active drug or an inactive pill (a placebo). Half of the group will receive the same treatment they were taking before the study -- this is called the "sham discontinuation" arm. The other half will receive a reduced dose of their medication, and then an inactive pill (placebo) -- this is called the "real discontinuation" arm. Participants will be able to return to their previous dose of medication at any time during the study. The percentage of people who return will be measured and compared. Other medical events and factors such as behaviors, thinking, and caregiver distress, will be measured and compared between the groups.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Stephen M Thielke, MD

    VA Puget Sound Health Care System Seattle Division, Seattle, WA

    Principal Investigator

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Central Arkansas Vhs John L. Mcclellan Memorial Veterans Hospital, Little Rock, Ar

    Little Rock, Arkansas, United States

  • Boise Va Medical Center, Boise, Id

    Boise, Idaho, United States

  • Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Ma

    Bedford, Massachusetts, United States

  • Va Puget Sound Health Care System Seattle Division, Seattle, Wa

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cholinesterase inhibitorSham discontinuation
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Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Jan 2015
Primary completion
1 Oct 2019
Completion
1 Oct 2019
Last update posted
23 Oct 2020
Registered enrollment
72
Registry id
NCT02248636

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.