Clinical trialNCT02258074CompletedPhase 2Interventional

The COMBINE Study: The CKD Optimal Management With BInders and NicotinamidE

SponsorThe Cleveland ClinicEnrollment205Chronic Kidney Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The COMBINE clinical trial is a pilot study evaluating the effects of nicotinamide and lanthanum carbonate on serum phosphate and fibroblast growth factor 23 (FGF23) in patients with Chronic Kidney Disease (CKD) stages 3-4.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Jennifer J Gassman, Ph.D.
Data Coordinating Center, Cleveland Clinic
Principal Investigator
clinicaltrials.gov ↗
John W. Kusek, PhD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study Director
clinicaltrials.gov ↗
Linda F Fried, MD
University of Pittsburgh
Study ChairKOL profile →
clinicaltrials.gov ↗
Michael F. Flessner, MD, PhD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California at San Diego
San Diego, California, United States
Denver Nephrology Research
Denver, Colorado, United States
George Washington University
Washington D.C., District of Columbia, United States
Northshore University Health System
Chicago, Illinois, United States
Northwestern University
Chicago, Illinois, United States
University of Utah
Salt Lake City, Utah, United States
Utah Va
Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Lanthanum carbonateNiacinamidePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2015
Primary completion: 30 Nov 2018
Completion: 30 Sept 2019
Last update posted: 2 Aug 2021
Registered enrollment: 205
Registry id: NCT02258074

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.