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Clinical trialNCT02374021CompletedPhase 4Interventional

Treatments Against RA and Effect on FDG-PET/CT

SponsorBrigham and Women's HospitalEnrollment159Arthritis, Rheumatoid
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

In a randomized controlled clinical trial, investigators will compare the effects on \[18F\]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) from two treatment regimens in rheumatoid arthritis (RA) patients deemed methotrexate inadequate responders (MTX-IRs). Two common RA treatments will be compared: triple therapy (sulfasalazine, methotrexate, and hydroxychloroquine) versus tumor necrosis factor (TNF) inhibitor (etanercept or adalimumab, plus background methotrexate for all subjects and hydroxychloroquine for subjects who were taking this at screening).

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

31 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama at Birmingham

    Birmingham, Alabama, United States

  • Loma Linda University Clinical Trial Center

    Loma Linda, California, United States

  • David Geffen School of Medicine at Ucla

    Los Angeles, California, United States

  • Brigid Freyne, Md Inc.

    Murrieta, California, United States

  • Desert Medical Advances

    Palm Desert, California, United States

  • University of California San Francisco

    San Francisco, California, United States

  • Nazanin Firooz Md, Inc.

    West Hills, California, United States

  • Robert W. Levin, Md, Pa

    Clearwater, Florida, United States

  • Iris Research and Development

    Plantation, Florida, United States

  • Southwest Florida Clinical Research Center

    Tampa, Florida, United States

  • University of Kentucky

    Lexington, Kentucky, United States

  • the Center for Rheumatology and Bone Research

    Wheaton, Maryland, United States

  • Brigham and Women'S Hospital

    Boston, Massachusetts, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, United States

  • University of Michigan

    Ann Arbor, Michigan, United States

  • Washington University Medical Center

    St Louis, Missouri, United States

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, United States

  • Northwell Health

    Great Neck, New York, United States

  • Columbia University Medical Center

    New York, New York, United States

  • Mount Sinai- Icahn School of Medicine

    New York, New York, United States

  • New York University School of Medicine

    New York, New York, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, United States

  • Cleveland Clinic

    Cleveland, Ohio, United States

  • Oregon Health & Science University

    Portland, Oregon, United States

  • Altoona Research Center

    Duncansville, Pennsylvania, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, United States

  • Metroplex Clinical Research Center

    Dallas, Texas, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, United States

  • Baylor Scott & White Medical Center- Temple

    Temple, Texas, United States

  • Seattle Rheumatology Associates

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jul 2016
Primary completion
31 May 2021
Completion
31 May 2021
Last update posted
26 Oct 2022
Registered enrollment
159
Registry id
NCT02374021

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.