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Clinical trialNCT02384200CompletedPhase 4Interventional

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

SponsorUniversity of California, San DiegoEnrollment86NephrolithiasisUrinary Tract Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

When patients are going to have surgery to remove large kidney stones (percutaneous nephrolithotomy \[PCNL\]), it is not clear whether the patients benefit from a course of prophylactic preoperative oral antibiotics; currently both the use of prophylactic preoperative oral antibiotics and no prophylactic oral antibiotics are considered to be within standard-of-care. This study will randomize patients to preoperative prophylactic antibiotics or no antibiotics to determine if the use of preoperative prophylactic antibiotics decreases the postoperative risk of localized urinary tract infection (UTI) and/or systemic infection that started in the urinary tract (sepsis or urosepsis).
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • University of British Columbia

    Vancouver, British Columbia, Canada

United States
  • Mayo Clinic in Arizona

    Phoenix, Arizona, United States

  • Ucsd Medical Center

    San Diego, California, United States

  • Ucsf

    San Francisco, California, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • Cleveland Clinic

    Cleveland, Ohio, United States

  • the Ohio State University Wexner Medical Center

    Columbus, Ohio, United States

  • Vanderbilt

    Nashville, Tennessee, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ampicillin →Ceftriaxone →Gentamicin →Nitrofurantoin →Vancomycin →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Mar 2015
Primary completion
1 Feb 2017
Completion
1 Jun 2019
Last update posted
22 Aug 2019
Registered enrollment
86
Registry id
NCT02384200
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.