Clinical trialNCT02455245CompletedPhase 3Interventional

A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma

SponsorAlicia LenzenEnrollment95Low Grade Glioma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is trying to learn and understand if the chemotherapy drug called carboplatin works as well as the standard therapy. The standard therapy for Low Grade Glioma (LGG) in children and young adults is using a combination of carboplatin and vincristine. Studies in children have shown that the use of carboplatin alone has promise of being just as effective for treating LGG as standard therapy. Additionally, this study will try to understand if treatment with carboplatin alone is associated with an improved quality of life for LGG patients and their families.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Alicia Lenzen, MD
Attending
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

21 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Phoenix Children'S Hospital
Phoeniz, Arizona, United States
Rady Children'S Hospital
San Diego, California, United States
Yale University
New Haven, Connecticut, United States
Orlando Health, Inc.
Orlando, Florida, United States
Ann & Robert H. Lurie Children'S Hosptial of Chicago
Chicago, Illinois, United States
St. Vincent Peyton Manning Children'S Hospital
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
the Johns Hopkins Hospital
Baltimore, Maryland, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
University of Michigan, C.S. Mott Children'S Hospital
Ann Arbor, Michigan, United States
Children'S Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States
Saint Louis University at Ssm Cardinal Glennon Children'S Medical Center
St Louis, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
Albany Medical Center
Albany, New York, United States
Duke University Medical School
Durham, North Carolina, United States
Children'S Hospital Medical Center of Akron
Akron, Ohio, United States
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Nationwide Children'S Hospital
Columbus, Ohio, United States
Dayton Children'S Hospital
Dayton, Ohio, United States
American Family Children'S Hospital
Madison, Wisconsin, United States
Medical College of Wiscosin
Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Carboplatin and Vincristine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2015
Primary completion: 31 Aug 2025
Completion: 30 Nov 2025
Last update posted: 2 Sept 2026
Registered enrollment: 95
Registry id: NCT02455245

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.