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Clinical trialNCT02481674CompletedPhase 2Interventional

A Study in Subjects With Late Prodromal & Early Manifest HD to Assess the Safety, Tolerability, pk, and Efficacy of Pepi

SponsorVaccinex Inc.Enrollment301Huntington's Disease
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the safety, tolerability, PK, and efficacy of Pepinemab in subjects with late prodromal and early manifest Huntington's disease.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

32 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • University of Alberta

    Edmonton, Alberta, Canada

  • University of British Columbia

    Vancouver, British Columbia, Canada

  • Centre Hospitalier de L'Université de Montréal (chum)

    Montreal, Quebec, Canada

United States
  • University of Alabama at Birmingham

    Birmingham, Alabama, United States

  • University of California, San Diego

    La Jolla, California, United States

  • University of California San Francisco

    San Francisco, California, United States

  • University of Colorado - Denver

    Aurora, Colorado, United States

  • Georgetown University

    Washington D.C., District of Columbia, United States

  • University of Florida Gainesville

    Gainesville, Florida, United States

  • Emory University School of Medicine

    Atlanta, Georgia, United States

  • Indiana University School of Medicine

    Indianapolis, Indiana, United States

  • University of Iowa

    Iowa City, Iowa, United States

  • University of Louisville

    Louisville, Kentucky, United States

  • Johns Hopkins University

    Baltimore, Maryland, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, United States

  • Massachusetts General Hospital

    Charlestown, Massachusetts, United States

  • University of Michigan

    Ann Arbor, Michigan, United States

  • Washington University

    St Louis, Missouri, United States

  • Columbia University

    New York, New York, United States

  • Columbia University

    New York, New York, United States

  • University of Rochester

    Rochester, New York, United States

  • Duke University Health Center

    Durham, North Carolina, United States

  • Wake Forest University

    Winston-Salem, North Carolina, United States

  • University of Cincinnati

    Cincinnati, Ohio, United States

  • Ohio State University

    Columbus, Ohio, United States

  • University of Toledo

    Toledo, Ohio, United States

  • Vanderbilt University

    Nashville, Tennessee, United States

  • University of Texas Houston Medical School

    Houston, Texas, United States

  • University of Vermont

    Burlington, Vermont, United States

  • Virginia Commonwealth University

    Richmond, Virginia, United States

  • University of Washington

    Seattle, Washington, United States

  • University of Washington and Va Puget Sound Health Care System

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboVX15/2503
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jul 2015
Primary completion
31 Aug 2020
Completion
31 Aug 2020
Last update posted
2 May 2022
Registered enrollment
301
Registry id
NCT02481674

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.