Clinical trialNCT02518594CompletedPhase 3Interventional

A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix

SponsorThe George Washington University Biostatistics CenterEnrollment1,311Short Cervical Length

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Joseph Biggio, MD
Maternal Fetal Medicine Units (MFMU) Network
Study Chair
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Monica Longo, MD
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Study Director
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

16 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama - Birmingham
Birmingham, Alabama, United States
the Regents of the University of California, San Francisco
San Francisco, California, United States
University of Colorado
Denver, Colorado, United States
Northwestern University-Prentice Hospital
Chicago, Illinois, United States
Columbia University
New York, New York, United States
University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, United States
Duke University
Durham, North Carolina, United States
Case Western Reserve University
Cleveland, Ohio, United States
Ohio State University
Columbus, Ohio, United States
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Magee Women'S Hospital
Pittsburgh, Pennsylvania, United States
Brown University
Providence, Rhode Island, United States
University of Texas - Galveston
Galveston, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
University of Texas - Houston
Houston, Texas, United States
University of Utah Medical Center
Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboVaginal progesterone

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Nov 2015
Primary completion: 15 Dec 2024
Completion: 18 Feb 2025
Last update posted: 25 Jun 2026
Registered enrollment: 1,311
Registry id: NCT02518594

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.