Clinical trialNCT02559206CompletedPhase 2Interventional

Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

SponsorIronwood Pharmaceuticals, Inc.Enrollment759Irritable Bowel Syndrome With Constipation

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objectives of this study are to evaluate the safety, efficacy, and dose response of two delayed release formulations of linaclotide (DR; DR formulation 1 is DR1; DR formulation 2 is DR2) administered orally to patients with irritable bowel syndrome with constipation (IBS-C). Additional objectives include understanding how the two DR formulations compare with each other and with the FDA-approved 290 μg LINZESS® (the immediate release \[IR\] formulation of linaclotide).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Paul Chamberlin, MD
Ironwood Pharmaceuticals, Inc.
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

71 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Ironwood Investigational Site
Huntsville, Alabama, United States
Ironwood Investigational Site
Phoenix, Arizona, United States
Ironwood Investigational Site
Tucson, Arizona, United States
Ironwood Investigational Site
North Little Rock, Arkansas, United States
Ironwood Investigational Site
Anaheim, California, United States
Ironwood Investigational Site
Chula Vista, California, United States
Ironwood Investigational Site
Garden Grove, California, United States
Ironwood Investigational Site
La Mesa, California, United States
Ironwood Investigational Site
Newport Beach, California, United States
Ironwood Investigational Site
Orange, California, United States
Ironwood Investigational Site
San Diego, California, United States
Ironwood Investigational Site
Thousand Oaks, California, United States
Ironwood Investigational Site
Colorado Springs, Colorado, United States
Ironwood Investigational Site
Bristol, Connecticut, United States
Ironwood Investigational Site
Waterbury, Connecticut, United States
Ironwood Investigational Site
Hialeah, Florida, United States
Ironwood Investigational Site
Kissimmee, Florida, United States
Ironwood Investigational Site
Miami, Florida, United States
Ironwood Investigational Site
Miami, Florida, United States
Ironwood Investigational Site
Miami, Florida, United States
Ironwood Investigational Site
Miami, Florida, United States
Ironwood Investigational Site
Orlando, Florida, United States
Ironwood Investigational Site
South Miami, Florida, United States
Ironwood Investigational Site
Tampa, Florida, United States
Ironwood Investigational Site
West Palm Beach, Florida, United States
Ironwood Investigational Site
Atlanta, Georgia, United States
Ironwood Investigational Site
Oakwood, Georgia, United States
Ironwood Investigational Site
Sandy Springs, Georgia, United States
Ironwood Investigational Site
Evansville, Indiana, United States
Ironwood Investigational Site
Bastrop, Louisiana, United States
Ironwood Investigational Site
Metairie, Louisiana, United States
Ironwood Investigational Site
Shreveport, Louisiana, United States
Ironwood Investigational Site
Baltimore, Maryland, United States
Ironwood Investigational Site
Chevy Chase, Maryland, United States
Ironwood Investigational Site
Boston, Massachusetts, United States
Ironwood Investigational Site
Watertown, Massachusetts, United States
Ironwood Investigational Site
Chesterfield, Michigan, United States
Ironwood Investigational Site
Wyoming, Michigan, United States
Ironwood Investigational Site
Jackson, Mississippi, United States
Ironwood Investigational Site
St Louis, Missouri, United States

31 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linaclotide →Matching Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Oct 2015
Primary completion: 30 Sept 2016
Completion: 30 Sept 2016
Last update posted: 24 Apr 2020
Registered enrollment: 759
Registry id: NCT02559206

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.