Clinical trialNCT02581137Active, not recruitingPhase 2Interventional

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

SponsorNational Cancer Institute (NCI)Enrollment26ErythroplakiaHyperplasiaOral Cavity CarcinomaOral Leukoplakia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase IIa trial studies how well metformin hydrochloride works in preventing oral cancer in patients with an oral premalignant lesion (oral leukoplakia or erythroplakia). Oral premalignant lesions look like red or whitish plaques or lesions in the mouth that do not rub off and can be associated with a higher risk of cancer. Metformin hydrochloride may help prevent oral cancer from forming in patients with an oral premalignant lesion.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Scott M Lippman
The University of Arizona Medical Center-University Campus
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Bc Cancer Research Centre
Vancouver, British Columbia, Canada
University of British Columbia Hospital
Vancouver, British Columbia, Canada

United States

Uc San Diego Medical Center - Hillcrest
San Diego, California, United States
University of Minnesota/masonic Cancer Center
Minneapolis, Minnesota, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Metformin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 10 Jun 2016
Primary completion: 12 Oct 2017
Completion: 19 Dec 2026
Last update posted: 26 Jun 2026
Registered enrollment: 26
Registry id: NCT02581137

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.