Clinical trialNCT02642393CompletedPhase 3Interventional

Study of Urate Elevation in Parkinson's Disease, Phase 3

SponsorMichael Alan SchwarzschildEnrollment298Parkinson's Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial to determine whether oral inosine dosed to moderately elevate serum urate (from ≤5.7 mg/dL to 7.1-8.0 mg/dL) over 2 years slows clinical decline in early PD. Clinical decline will be assessed as change in the primary outcome variable of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), a composite scale comprising patient- and clinician-reported outcomes.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Alberto Ascherio, MD, DrPH
Harvard School of Public Health, PSG (Co-Chair, SURE-PD3 Steering Committee)
Study Director
clinicaltrials.gov ↗
David Oakes, PhD
University of Rochester (PI of Data Coordinating Center), PSG (Study Statistician/Member, SURE-PD3 Steering Committee)
Study Director
clinicaltrials.gov ↗
Eric A Macklin, PhD
Massachusetts General Hospital, PSG (Study Statistician/Member, SURE-PD3 Steering Committee)
Study Director
clinicaltrials.gov ↗
Michael A Schwarzschild, MD, PhD
Massachusetts General Hospital (PI of Clinical Coordinating Center), PSG (Chair, SURE-PD3 Steering Committee)
Study ChairKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

62 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

University of Puerto Rico
San Juan, Massachusetts, Puerto Rico

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
Barrow Neurological Institute
Phoenix, Arizona, United States
Mayo Clinic Arizona
Scottsdale, Arizona, United States
Banner Sun Health Research Institute
Sun City, Arizona, United States
University of California San Diego
La Jolla, California, United States
University of Southern California
Los Angeles, California, United States
University of California Davis
Sacramento, California, United States
University of California San Francisco
San Francisco, California, United States
University of Colorado
Aurora, Colorado, United States
Rocky Mountain Movement Disorder Center
Englewood, Colorado, United States
Hartford Healthcare Movement Disorders Center
Vernon, Connecticut, United States
University of South Florida
Tampa, Florida, United States
Emory University
Atlanta, Georgia, United States
Augusta University
Augusta, Georgia, United States
Northwestern University
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
Neurosciences Institute at Central Dupage Hospital
Winfield, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
University of Louisville
Louisville, Kentucky, United States
Oschner Clinic Foundation
New Orleans, Louisiana, United States
Johns Hopkins University
Baltimore, Maryland, United States
University of Maryland, Baltimore
Baltimore, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Boston University Medical Center
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Michigan State University
East Lansing, Michigan, United States
Henry Ford Health System
West Bloomfield, Michigan, United States
Washington University School of Medicine
St Louis, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada, United States
Overlook Medical Center, Atlantic Neuroscience Institute
Summit, New Jersey, United States
Albany Medical College
Albany, New York, United States
Suny Downstate Medical Center
Brooklyn, New York, United States
Weill Cornell Medical Center
New York, New York, United States
Suny Upstate Medical University
Syracuse, New York, United States
Duke University
Durham, North Carolina, United States
University of Cincinnati/cincinnati Children'S Hospital
Cincinnati, Ohio, United States

22 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

InosinePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 2016
Primary completion: 30 Jun 2019
Completion: 30 Jun 2019
Last update posted: 28 Jul 2020
Registered enrollment: 298
Registry id: NCT02642393

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.