Clinical trialNCT02713386CompletedPhase 1/PHASE2Interventional

Ruxolitinib Phosphate, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

SponsorNRG OncologyEnrollment147FIGO Stage III Ovarian Cancer 2014FIGO Stage IIIA Ovarian Cancer 2014FIGO Stage IIIA1 Ovarian CancerFIGO Stage IIIA2 Ovarian CancerFIGO Stage IIIB Ovarian Cancer 2014FIGO Stage IIIC Ovarian Cancer 2014+20 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II trial studies the side effects and the best dose of ruxolitinib phosphate when given together with paclitaxel and carboplatin and to see how well they work in treating patients with stage III-IV epithelial ovarian, fallopian tube, or primary peritoneal cancer. Ruxolitinib phosphate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ruxolitinib phosphate together with paclitaxel and carboplatin may be a better treatment for epithelial ovarian, fallopian tube, or primary peritoneal cancer compared to paclitaxel and carboplatin alone.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Charles N Landen
NRG Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

110 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Ctca at Western Regional Medical Center
Goodyear, Arizona, United States
Sutter Auburn Faith Hospital
Auburn, California, United States
Ucla / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States
Sutter Roseville Medical Center
Roseville, California, United States
Sutter Medical Center Sacramento
Sacramento, California, United States
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States
Danbury Hospital
Danbury, Connecticut, United States
Norwalk Hospital
Norwalk, Connecticut, United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States
Helen F Graham Cancer Center
Newark, Delaware, United States
Beebe Health Campus
Rehoboth Beach, Delaware, United States
Sarasota Memorial Hospital
Sarasota, Florida, United States
Northside Hospital
Atlanta, Georgia, United States
Augusta University Medical Center
Augusta, Georgia, United States
Lewis Cancer and Research Pavilion at Saint Joseph'S/candler
Savannah, Georgia, United States
Memorial Health University Medical Center
Savannah, Georgia, United States
Summit Cancer Care-Candler
Savannah, Georgia, United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States
Northwestern University
Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Carle at the Riverfront
Danville, Illinois, United States
Carle Physician Group-Effingham
Effingham, Illinois, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Uc Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois, United States
Carle Cancer Center
Urbana, Illinois, United States
the Carle Foundation Hospital
Urbana, Illinois, United States
Midwestern Regional Medical Center
Zion, Illinois, United States
Parkview Regional Medical Center
Fort Wayne, Indiana, United States
Ascension Saint Vincent Indianapolis Hospital
Indianapolis, Indiana, United States
University of Iowa/holden Comprehensive Cancer Center
Iowa City, Iowa, United States
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky, United States
Norton Suburban Hospital and Medical Campus
Louisville, Kentucky, United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States
Woman'S Hospital
Baton Rouge, Louisiana, United States
Women'S Cancer Care-Covington
Covington, Louisiana, United States
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States
Johns Hopkins University/sidney Kimmel Cancer Center
Baltimore, Maryland, United States
Umass Memorial Medical Center - Memorial Division
Worcester, Massachusetts, United States

70 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Paclitaxel →Ruxolitinib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Nov 2016
Primary completion: 30 Sept 2021
Completion: 22 May 2024
Last update posted: 25 May 2025
Registered enrollment: 147
Registry id: NCT02713386

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.