Clinical trialNCT02724527UnknownPhase 2Interventional

Study of Cavosonstat (N91115) in CF Patients Who Are Heterozygous for F508del-CFTR and a Gating Mutation and Being Treated With Ivacaftor

SponsorNivalis Therapeutics, Inc.Enrollment19Cystic Fibrosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Cavosonstat (N91115) is being studied as a potential novel therapy for cystic fibrosis (CF), and this study assesses a target population of patients who are heterozygous for F508del-CFTR and a gating mutation that is approved for treatment with ivacaftor (G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N, or S549R).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

James Chmiel, MD
Rainbow Babies and Children's Hospital/ University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

National Jewish Health
Denver, Colorado, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Boston Children'S Hospital
Boston, Massachusetts, United States
Washington University
St Louis, Missouri, United States
Columbia University
New York, New York, United States
Cincinnati Children'S Hospital
Cincinnati, Ohio, United States
Rainbow Babies and Children'S Hospital - Case Medical Center
Cleveland, Ohio, United States
Nationwide Children'S Hospital
Columbus, Ohio, United States
Oregon Health and Science University
Portland, Oregon, United States
Children'S Hospital Pittsburgh
Pittsburgh, Pennsylvania, United States
University of Utah
Salt Lake City, Utah, United States
Medical Center of Wisconsin
Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CavosonstatPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2016
Primary completion: 30 Apr 2017
Completion: 30 Apr 2017
Last update posted: 21 Nov 2016
Registered enrollment: 19
Registry id: NCT02724527

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.