Clinical trialNCT02750319Active, not recruitingPhase 3Interventional

Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery

SponsorMemorial Sloan Kettering Cancer CenterEnrollment184Atrial Fibrillation in High Risk PatientsThoracic Surgery

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This trial will be comparing the combination of amiodarone and NAC (n=122) to amiodarone alone and NAC matched placebo (n=122) to determine the rates with which sustained (lasting \>30 seconds) or clinically significant POAF is reduced in high risk patients within 7 days after major thoracic surgery.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David Amar, MD
Memorial Sloan Kettering Cancer Center
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Washington School of Medicine in St. Louis
St Louis, Missouri, United States
Memorial Sloan Kettering Basking Ridge (consent Only)
Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth (consent Only)
Middletown, New Jersey, United States
Memorial Sloan Kettering Bergen (consent Only)
Montvale, New Jersey, United States
Memorial Sloan Kettering Commack (consent Only)
Commack, New York, United States
Memorial Sloan Kettering Westchester (consent Only)
Harrison, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Memorial Sloan Kettering Rockville Centre (consent Only)
Rockville Centre, New York, United States
Memorial Sloan Kettering Nassau (consent Only)
Uniondale, New York, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AmiodaroneAcetylcysteinePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2016
Primary completion: 30 Apr 2027
Completion: 30 Apr 2027
Last update posted: 19 May 2026
Registered enrollment: 184
Registry id: NCT02750319

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.