Clinical trialNCT02752789CompletedObservational

Impact of Allo- and Autoantibodies on Chronic Cardiac Allograft Function

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment407Pediatric Heart Transplant RecipientsPediatric Heart Transplantation

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi-center, prospective, single cohort, observational study of pediatric heart transplant recipients designed to determine the impact of preformed versus de novo human leukocyte antigen (HLA) donor-specific antibodies (DSA), and antibodies to the self-antigens cardiac myosin and vimentin, on chronic allograft function. In addition, the investigators will explore mechanisms of action and predictors of DSA, rejection and altered pathophysiology.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Steven A. Webber, MBChB, MRCP
Monroe Carell Jr. Children's Hospital at Vanderbilt: Pediatric Transplantation
Principal Investigator
clinicaltrials.gov ↗
Steven A. Webber, MBChB, MRCP
Monroe Carell Jr. Children's Hospital at Vanderbilt: Pediatric Transplantation
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Hospital for Sick Children
Toronto, Canada

United States

Emory University School of Medicine
Atlanta, Georgia, United States
Children'S Hospital Boston
Boston, Massachusetts, United States
St. Louis Children'S Hospital
St Louis, Missouri, United States
Children'S Hospital at Montefiore
New York, New York, United States
Columbia University Medical Center
New York, New York, United States
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Children'S Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States
Monroe Carell Jr. Children'S Hospital
Nashville, Tennessee, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 15 Jul 2014
Primary completion: 1 Nov 2019
Completion: 1 Nov 2019
Last update posted: 29 Nov 2019
Registered enrollment: 407
Registry id: NCT02752789

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.