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Clinical trialNCT02772003Active, not recruitingPhase 1Interventional

DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection

SponsorNational Cancer Institute (NCI)Enrollment33Chronic HepatitisHepatitis C InfectionHepatocellular Carcinoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I trial studies the side effects and best dose of deoxyribonucleic acid (DNA) vaccine therapy in treating patients with hepatitis C virus (HCV) infection that persists or progresses over a long period of time. Vaccines made from DNA may help the body build an effective immune response to kill cancer cells that express HCV infection.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico
  • University of Puerto Rico

    San Juan, Puerto Rico

United States
  • Mayo Clinic in Florida

    Jacksonville, Florida, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, United States

  • Case Western Reserve University

    Cleveland, Ohio, United States

  • Temple University Hospital

    Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Electroporation-Mediated Plasmid DNA Vaccine TherapyHCV DNA Vaccine INO-8000Rocakinogene sifuplasmid
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
6 Jun 2016
Primary completion
4 Mar 2020
Completion
9 Mar 2027
Last update posted
28 Jul 2026
Registered enrollment
33
Registry id
NCT02772003
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.