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Clinical trialNCT02773849CompletedPhase 3Interventional

ADSTILADRIN (=INSTILADRIN) in Patients With High-Grade, Bacillus Calmette-Guerin (BCG) Unresponsive Non-Muscle Invasive Bladder Cancer (NMIBC)

SponsorFerring PharmaceuticalsEnrollment157Superficial Bladder Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Previous multi-dose Phase I and Phase II clinical studies have demonstrated that ADSTILADRIN is a safe and effective treatment for BCG-refractory and recurrent NMIBC. This Phase III study is designed to expand those observations using a high dose of ADSTILADRIN in patients that are "BCG Unresponsive" which refers to patients with high-grade NMIBC who are unlikely to benefit from and should not receive further intravesical BCG.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

34 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Banner Md Anderson Cancer Center

    Gilbert, Arizona, United States

  • Keck School of Medicine at Usc Medical Center

    Los Angeles, California, United States

  • the Urology Center of Colorado

    Denver, Colorado, United States

  • University of Florida - Uf Health Davis Center Pavilion and Shands Med Plaza

    Gainesville, Florida, United States

  • H. Lee Moffitt Cancer Center & Research Institute

    Tampa, Florida, United States

  • Emory University School of Medicine

    Atlanta, Georgia, United States

  • University of Chicago - Comprehensive Cancer Research Center

    Chicago, Illinois, United States

  • Ochsner Clinic Foundation

    New Orleans, Louisiana, United States

  • Johns Hopkins Kimmel Cancer Center

    Baltimore, Maryland, United States

  • University of Michigan

    Ann Arbor, Michigan, United States

  • Spectrum Health Medical Group

    Grand Rapids, Michigan, United States

  • University of Minnesota

    Minneapolis, Minnesota, United States

  • Mayo Clinic - Rochester

    Rochester, Minnesota, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Delaware Valley Urology, Llc

    Voorhees Township, New Jersey, United States

  • Suny Upstate Medical Center

    Syracuse, New York, United States

  • Montefiore Medical Center

    The Bronx, New York, United States

  • University of North Carolina (unc) - Chapel Hill

    Chapel Hill, North Carolina, United States

  • Duke University

    Durham, North Carolina, United States

  • the University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, United States

  • Penn State Milton S. Hershey Medical Center

    Hershey, Pennsylvania, United States

  • the Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, United States

  • Regional Urology

    Greenville, South Carolina, United States

  • Carolina Urologic Research Center

    Myrtle Beach, South Carolina, United States

  • Vanderbilt University Medical Center Dept. of Urologic Surgery

    Nashville, Tennessee, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, United States

  • Baylor College of Medicine

    Houston, Texas, United States

  • Md Anderson Cancer Center

    Houston, Texas, United States

  • the Univ. of Texas Health Science Center at San Antonio

    San Antonio, Texas, United States

  • University of Virginia Health System

    Charlottesville, Virginia, United States

  • Urology of Virginia

    Virginia Beach, Virginia, United States

  • West Virginia University Cancer Institute

    Morgantown, West Virginia, United States

  • University of Wisconsin - Madison

    Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Nadofaragene firadenovec
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
19 Sept 2016
Primary completion
24 May 2019
Completion
24 May 2023
Last update posted
29 Jul 2024
Registered enrollment
157
Registry id
NCT02773849

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.