Clinical trialNCT02811263CompletedPhase 3Interventional

High-dose Erythropoietin for Asphyxia and Encephalopathy

SponsorUniversity of California, San FranciscoEnrollment500Birth AsphyxiaNeonatal Encephalopathy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Hypoxic-ischemic encephalopathy (HIE) occurs when a baby gets reduced blood flow and oxygen to the brain near the time of birth. This results in death or neurologic disabilities including cerebral palsy and cognitive impairment in up to half of affected infants. This clinical trial will determine if the drug erythropoietin (Epo) added to hypothermia (usual therapy) will improve outcomes for infants suffering from HIE.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Sandra Juul, MD PHD
University of Washington
Principal Investigator
clinicaltrials.gov ↗
Yvonne Wu, MD MPH
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

23 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital Los Angeles
Los Angeles, California, United States
Stanford University
Palo Alto, California, United States
University of California, San Francisco
San Francisco, California, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Indiana University
Indianapolis, Indiana, United States
Children'S Hospitals and Clinics of Minnesota: Minneapolis
Minneapolis, Minnesota, United States
Children'S Hospitals and Clinics of Minnesota: St. Paul
Saint Paul, Minnesota, United States
Washington University
St Louis, Missouri, United States
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Good Samaritan Hospital
Cincinnati, Ohio, United States
Nationwide Children'S Hospital
Columbus, Ohio, United States
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Children'S Hospital of Pittsburgh of Upmc
Pittsburgh, Pennsylvania, United States
Magee Women'S Hospital of Upmc
Pittsburgh, Pennsylvania, United States
Vanderbilt University
Nashville, Tennessee, United States
Ut Southwestern
Dallas, Texas, United States
Cook Children'S Hospital
Fort Worth, Texas, United States
Children'S Hospital of San Antonio
San Antonio, Texas, United States
Methodist Children'S Hospital
San Antonio, Texas, United States
Primary Children'S Hospital
Salt Lake City, Utah, United States
University of Utah
Salt Lake City, Utah, United States
Seattle Children'S Hospital
Seattle, Washington, United States
University of Washington Medical Center
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Epoetin alfa →Normal saline placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 2017
Primary completion: 31 Oct 2021
Completion: 30 Apr 2022
Last update posted: 30 Jan 2023
Registered enrollment: 500
Registry id: NCT02811263

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.