Clinical trialNCT02912312Active, not recruitingPhase 2Interventional

Hypofractionated vs. Conventional Regional Nodal Radiation Therapy for Patients With Invasive Breast Cancer

SponsorM.D. Anderson Cancer CenterEnrollment805Invasive Breast CarcinomaStage I Breast Cancer AJCC v7Stage IA Breast Cancer AJCC v7Stage IB Breast Cancer AJCC v7Stage II Breast Cancer AJCC v6 and v7Stage IIA Breast Cancer AJCC v6 and v7+3 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

To compare how often cancer recurs (comes back) after 3 weeks of radiation compared to 5 weeks of radiation in patients who receive radiation therapy delivered to the lymph nodes near the breast. The side effects that can develop during or after radiation treatment, including how often arm swelling (edema) happens, will also be studied.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Karen Hoffman, MD
M.D. Anderson Cancer Center
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Md Anderson Cancer Center (banner)
Gilbert, Arizona, United States
Scripps- Md Anderson Cancer
San Diego, California, United States
Md Anderson Cancer Center (banner)- Northern Colorado
Greeley, Colorado, United States
Baptist - Md Anderson Cancer Center
Jacksonville, Florida, United States
Orlando Health Cancer Institute
Orlando, Florida, United States
Community Md Anderson Cancer Center East
Indianapolis, Indiana, United States
Community Md Anderson Cancer Center North
Indianapolis, Indiana, United States
Community Md Anderson Cancer Center South
Indianapolis, Indiana, United States
Cooper Hospital University Medical Center
Camden, New Jersey, United States
Ohio Health
Columbus, Ohio, United States
M D Anderson Cancer Center
Houston, Texas, United States
Ut Health San Antonio - Md Anderson Cancer Center
San Antonio, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 23 Feb 2017
Primary completion: 28 Feb 2030
Completion: 28 Feb 2031
Last update posted: 15 Jul 2026
Registered enrollment: 805
Registry id: NCT02912312

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.