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Clinical trialNCT02912559Active, not recruitingPhase 3Interventional

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

SponsorNational Cancer Institute (NCI)Enrollment712Colon AdenocarcinomaDNA Repair DisorderLynch SyndromeStage III Colon Cancer AJCC v8
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR). Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving combination chemotherapy with atezolizumab may work better than combination chemotherapy alone in treating patients with dMMR colon cancer.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1,049 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Germany
  • Technical University Dresden

    Dresden, Saxony, Germany

  • Charite Humboldt - University Hospital

    Berlin, Germany

  • Saint Josef-Hospital Bochum

    Bochum, Germany

  • Onkologie-Cologne

    Cologne, Germany

  • Klinikum Esslingen Gmbh

    Esslingen am Neckar, Germany

  • Hamatologisch-Onkologische Praxis Eppendorf (hope)

    Hamburg, Germany

  • Universitaet Leipzig

    Leipzig, Germany

  • Medizinische Universitat

    Mannheim, Germany

  • Kliniken Maria Hilf Gmbh

    Mönchengladbach, Germany

  • Medizinische Klinik Iii

    München, Germany

  • University Hospital Ulm

    Ulm, Germany

  • University Hospital Wuerzburg

    Würzburg, Germany

Puerto Rico
  • Advance Oncology Center

    Aguadilla, Puerto Rico

  • Doctor'S Cancer Center-Arecibo

    Arecibo, Puerto Rico

  • Cancer Center-Metro Medical Center Bayamon

    Bayamón, Puerto Rico

  • Hematologia Oncologia San Pablo

    Bayamón, Puerto Rico

  • Hima San Pablo Oncologic Hospital

    Caguas, Puerto Rico

  • Doctors Cancer Center

    Manati, Puerto Rico

  • Instituto Oncologia Moderna Ponce

    Ponce, Puerto Rico

  • Primary Care Physician Group

    San Juan, Puerto Rico

  • San Juan City Hospital

    San Juan, Puerto Rico

  • San Juan Community Oncology Group

    San Juan, Puerto Rico

  • Centro de Hematologia Y Oncologia del Sur

    Santa Isabel, Puerto Rico

United States
  • Alaska Breast Care and Surgery Llc

    Anchorage, Alaska, United States

  • Alaska Oncology and Hematology Llc

    Anchorage, Alaska, United States

  • Alaska Women'S Cancer Care

    Anchorage, Alaska, United States

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, United States

  • Anchorage Oncology Centre

    Anchorage, Alaska, United States

  • Katmai Oncology Group

    Anchorage, Alaska, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, United States

  • Fairbanks Memorial Hospital

    Fairbanks, Alaska, United States

  • Cancer Center at Saint Joseph'S

    Phoenix, Arizona, United States

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona, United States

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, United States

  • Banner University Medical Center - Tucson

    Tucson, Arizona, United States

  • University of Arizona Cancer Center-North Campus

    Tucson, Arizona, United States

  • Chi Saint Vincent Cancer Center Hot Springs

    Hot Springs, Arkansas, United States

  • Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    Jonesboro, Arkansas, United States

  • Kaiser Permanente-Anaheim

    Anaheim, California, United States

  • Pcr Oncology

    Arroyo Grande, California, United States

1,009 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Atezolizumab →Fluorouracil →Leucovorin →Oxaliplatin →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
16 Oct 2017
Primary completion
4 Feb 2025
Completion
18 Dec 2026
Last update posted
4 Aug 2026
Registered enrollment
712
Registry id
NCT02912559
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.