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Clinical trialNCT02935517UnknownPhase 1/PHASE2Interventional

Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGA3 Achromatopsia (A Clarity Clinical Trial)

SponsorBeacon TherapeuticsEnrollment24Achromatopsia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This will be a non-randomized, open-label, Phase 1/2 study of the safety and efficacy of AGTC-402, administered to one eye by subretinal injection in individuals with achromatopsia caused by mutations in the CNGA3 gene. The primary study endpoint will be safety and the secondary study endpoint will be efficacy.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Israel
  • Hadassah-Hebrew University Medical Center

    Jerusalem, Israel

United States
  • Vitreoretinal Associates

    Gainesville, Florida, United States

  • Bascom Palmer Eye Institute

    Miami, Florida, United States

  • Massachusetts Eye and Ear Infirmary

    Boston, Massachusetts, United States

  • Cincinnati Eye Institute

    Cincinnati, Ohio, United States

  • Casey Eye Institute, Oregon Health and Sciences University

    Portland, Oregon, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AGTC-402
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
3 Aug 2017
Primary completion
31 Aug 2022
Completion
31 Aug 2026
Last update posted
22 Jul 2022
Registered enrollment
24
Registry id
NCT02935517
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.