findmyKOL
Clinical trialNCT02979340CompletedObservational

MRI to Characterize and Predict CF Liver Disease in PUSH Cohort

SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Enrollment115Cystic Fibrosis Liver DiseasePancreatic Insufficiency
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Specific Aim 1. Determine if valid results of non-sedated MRI based assessments of liver stiffness and lipid content can be obtained in more than 90% of children and young adults with cystic fibrosis. Specific Aim 2. Determine hepatic lipid content using the HepaFat sequence and liver stiffness using MRE. Investigators will compare the results obtained by MRI with PUSH study grayscale ultrasounds in CF patients with normal, heterogeneous, homogeneous or nodular (cirrhotic) pattern on ultrasound. Specific Aim 3. Creation of an imaging core lab to centralize evaluation of MR imaging data, allow for remote image upload, electronic data storage, and remote image viewing/interpretation. This infrastructure will be utilized to standardize image post processing. Specific Aim 4. Using the longitudinal PUSH study, determine if MRI based imaging improves discrimination of subjects at risk for progression to advanced CF liver disease (development of cirrhosis) compared to using US imaging alone
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Averell Sherker, MD

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    Study Director
    clinicaltrials.gov ↗
  • Ed Doo, MD

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    Study Director
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • Children'S Healthcare of Atlanta

    Atlanta, Georgia, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, United States

  • Johns Hopkins School of Medicine

    Baltimore, Maryland, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Cincinnati Children'S Hospital Medical

    Cincinnati, Ohio, United States

  • Texas Children'S Hospital

    Houston, Texas, United States

  • Seattle Children'S Hospital

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
27 Jan 2017
Primary completion
27 Dec 2019
Completion
27 Dec 2019
Last update posted
11 Apr 2025
Registered enrollment
115
Registry id
NCT02979340
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.