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Clinical trialNCT03050450TerminatedPhase 1Interventional

Study of Lenalidomide With Vorinostat in Pediatric Patients With High Grade or Progressive CNS Tumors

SponsorJohns Hopkins All Children's HospitalEnrollment8Central Nervous System Tumors
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Independently, both lenalidomide and vorinostat have shown promising activity in pediatric central nervous system (CNS) tumors. These are both agents that are not typically part of first-line studies, although both agents are of serious interest and are currently in clinical trials for further investigation. This study is to evaluate the combination of lenalidomide and vorinostat in high grade or progressive central nervous system tumors in children.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Johns Hopkins All Childen'S Hospital

    St. Petersburg, Florida, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

100 mg/m2 Lenalidomide and 180 mg/m2 Vorinostat150 mg/m2 Lenalidomide and 180 mg/m2 Vorinostat150 mg/m2 Lenalidomide and 230 mg/m2 Vorinostat25 mg/m2 Lenalidomide and 180 mg/m2 Vorinostat50 mg/m2 Lenalidomide and 180 mg/m2 Vorinostat
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
10 Aug 2016
Primary completion
19 Dec 2018
Completion
19 Dec 2018
Last update posted
5 Apr 2021
Registered enrollment
8
Registry id
NCT03050450
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.