FindMyKOL
Clinical trialNCT03057054Active, not recruitingPhase 3Interventional

Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

SponsorChildren's Oncology GroupEnrollment173Acute Graft Versus Host DiseaseHematopoietic and Lymphatic System NeoplasmLeukemiaLymphoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase III trial studies how well Lactobacillus plantarum works in preventing acute graft versus host disease in children undergoing donor stem cell transplant. Lactobacillus plantarum may help prevent the development of gastrointestinal graft versus host disease in children, adolescents, and young adults undergoing donor stem cell transplant.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

43 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Alberta Children'S Hospital

    Calgary, Alberta, Canada

  • Hospital for Sick Children

    Toronto, Ontario, Canada

  • Centre Hospitalier Universitaire Sainte-Justine

    Montreal, Quebec, Canada

United States
  • Children'S Hospital of Alabama

    Birmingham, Alabama, United States

  • City of Hope Comprehensive Cancer Center

    Duarte, California, United States

  • Children'S Hospital Los Angeles

    Los Angeles, California, United States

  • Ucsf Benioff Children'S Hospital Oakland

    Oakland, California, United States

  • Rady Children'S Hospital - San Diego

    San Diego, California, United States

  • Ucsf Medical Center-Mission Bay

    San Francisco, California, United States

  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • Yale University

    New Haven, Connecticut, United States

  • Alfred I Dupont Hospital for Children

    Wilmington, Delaware, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • University of Florida Health Science Center - Gainesville

    Gainesville, Florida, United States

  • Nemours Children'S Clinic-Jacksonville

    Jacksonville, Florida, United States

  • Nemours Children'S Hospital

    Orlando, Florida, United States

  • Johns Hopkins All Children'S Hospital

    St. Petersburg, Florida, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, United States

  • Children'S Hospital New Orleans

    New Orleans, Louisiana, United States

  • Johns Hopkins University/sidney Kimmel Cancer Center

    Baltimore, Maryland, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • C S Mott Children'S Hospital

    Ann Arbor, Michigan, United States

  • Corewell Health Grand Rapids Hospitals - Helen Devos Children'S Hospital

    Grand Rapids, Michigan, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, United States

  • Children'S Mercy Hospitals and Clinics

    Kansas City, Missouri, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, United States

  • Nyp/columbia University Medical Center/herbert Irving Comprehensive Cancer Center

    New York, New York, United States

  • University of Rochester

    Rochester, New York, United States

  • New York Medical College

    Valhalla, New York, United States

  • Unc Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, United States

  • Nationwide Children'S Hospital

    Columbus, Ohio, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, United States

  • Oregon Health and Science University

    Portland, Oregon, United States

  • Children'S Hospital of Philadelphia

    Philadelphia, Pennsylvania, United States

  • the Children'S Hospital at Tristar Centennial

    Nashville, Tennessee, United States

  • Vanderbilt University/ingram Cancer Center

    Nashville, Tennessee, United States

  • Medical City Dallas Hospital

    Dallas, Texas, United States

3 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Lactobacillus plantarum strain 299Lactobacillus plantarum strain 299v
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Apr 2018
Primary completion
30 Jun 2022
Completion
30 Jun 2026
Last update posted
6 Oct 2025
Registered enrollment
173
Registry id
NCT03057054

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.