Clinical trialNCT03070223CompletedPhase 3Interventional

PREPARE (A5361s) Ancillary Study of REPRIEVE (A5332)

SponsorAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsEnrollment602HIV-1 Infection

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Aging with HIV is associated with earlier development of frailty (weakness) or disability, including loss of physical and muscle strength, and walking speed. Few treatments have been shown to prevent or slow these impairments in people with or without HIV. Some studies have suggested that the class of drugs called statins (for example, pitavastatin) might be helpful in slowing frailty or disability. This might happen by decreasing fat within the muscle or by decreasing inflammation markers (substances in the blood that determine how the body reacts to infection or irritation) in the blood. Other studies have shown that statins increase the risk of muscle aches and pains. This ancillary study was done to determine the impact of the drug pitavastatin on physical and muscle function.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Kristine Erlandson, MD
University of Colorado, Denver
Study ChairKOL profile →
clinicaltrials.gov ↗
Todd Brown, MD, PhD
Johns Hopkins University
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

31 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Puerto Rico-Aids Crs (5401)
San Juan, PR, Puerto Rico

United States

Alabama Crs (31788)
Birmingham, Alabama, United States
University of California, Los Angeles Care Center Crs (601)
Los Angeles, California, United States
University of Southern California (1201)
Los Angeles, California, United States
Ucsd, Avrc Crs (701)
San Diego, California, United States
Ucsf Aids Crs (801)
San Francisco, California, United States
Harbor-Ucla Med. Ctr. Crs (603)
Torrance, California, United States
University of Colorado Hospital Crs (6101)
Aurora, Colorado, United States
2701 Northwestern University Crs
Chicago, Illinois, United States
Rush Univ. Med. Ctr. Actg Crs (2702)
Chicago, Illinois, United States
Johns Hopkins University Crs (201)
Baltimore, Maryland, United States
Brigham and Women'S Hosp. Actg Crs (107)
Boston, Massachusetts, United States
Massachusetts General Hospital (mgh) Crs (101)
Boston, Massachusetts, United States
Washington University Crs (2101)
St Louis, Missouri, United States
New Jersey Medical School Clinical Research Center Crs (31786)
Newark, New Jersey, United States
Columbia Physicians and Surgeons Crs (30329)
New York, New York, United States
Weill Cornell Chelsea Crs (7804)
New York, New York, United States
Weill Med. College of Cornell Univ., the Cornell Ctu -Chelsea (7803)
New York, New York, United States
University of Rochester Adult Hiv Therapeutic Strategies Network Crs (31787)
Rochester, New York, United States
Unc Aids Crs (3201)
Chapel Hill, North Carolina, United States
Greensboro Crs (3203)
Greensboro, North Carolina, United States
Univ. of Cincinnati Crs (2401)
Cincinnati, Ohio, United States
Case Crs (2501)
Cleveland, Ohio, United States
the Ohio State Univ. Aids Crs (2301)
Columbus, Ohio, United States
Hosp. of the Univ. of Pennsylvania Crs (6201)
Philadelphia, Pennsylvania, United States
Pittsburgh Crs (1001)
Pittsburgh, Pennsylvania, United States
the Miriam Hospital (tmh) Actg Crs (2951)
Providence, Rhode Island, United States
Vanderbilt Therapeutics Crs (3652)
Nashville, Tennessee, United States
Trinity Health and Wellness Center Crs (31443)
Dallas, Texas, United States
Houston Aids Research Team (hart) Crs (31473)
Houston, Texas, United States
University of Washington Aids Crs (1401)
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pitavastatin →Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Mar 2017
Primary completion: 21 Aug 2023
Completion: 21 Aug 2023
Last update posted: 28 Oct 2024
Registered enrollment: 602
Registry id: NCT03070223

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.