Clinical trialNCT03161028CompletedPhase 2Interventional

Lipoic Acid for Progressive Multiple Sclerosis (MS)

SponsorVA Office of Research and DevelopmentEnrollment115Multiple Sclerosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the study is to determine if lipoic acid can preserve mobility and protect the brain in progressive forms of multiple sclerosis.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Rebecca I. Spain, MD MSPH
VA Portland Health Care System, Portland, OR
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

11 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Ottawa Hospital Research Institute
Ottawa, Ontario, Canada

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Colorado
Aurora, Colorado, United States
Washington Dc Va Medical Center, Washington, Dc
Washington D.C., District of Columbia, United States
Va Portland Health Care System, Portland, Or
Portland, Oregon, United States
Va North Texas Health Care System Dallas Va Medical Center, Dallas, Tx
Dallas, Texas, United States
University of Utah
Salt Lake City, Utah, United States
Va Salt Lake City Health Care System, Salt Lake City, Ut
Salt Lake City, Utah, United States
University of Vermont
Burlington, Vermont, United States
Swedish Medical Center
Seattle, Washington, United States
Va Puget Sound Health Care System Seattle Division, Seattle, Wa
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ThioctatePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 17 Aug 2018
Primary completion: 31 Dec 2023
Completion: 30 Jun 2024
Last update posted: 3 Mar 2025
Registered enrollment: 115
Registry id: NCT03161028

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.