Clinical trialNCT03192215TerminatedPhase 3Interventional

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

SponsorColumbia UniversityEnrollment1,015Stroke

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Objectives * Primary: To test the hypothesis that apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy. * Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Randolph S Marshall, MD
Columbia University
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

177 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

University of Calgary - Foothills Medical Centre
Calgary, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Neurologic Research Center
Lethbridge, Alberta, Canada
Kelowna General Hospital
Kelowna, British Columbia, Canada
Vancouver General Hospital
Vancouver, British Columbia, Canada
Brandon Regional Health Center
Brandon, Manitoba, Canada
Hamilton General Hospital
Hamilton, Ontario, Canada
Kingston General Hospital
Kingston, Ontario, Canada
London Health Sciences Center
London, Ontario, Canada
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada
Enfant-Jesus Hospital
Québec, Quebec, Canada
Royal University Hospital
Saskatoon, Saskatchewan, Canada

United States

University of Alabama
Birmingham, Alabama, United States
University of South Alabama University Hospital
Mobile, Alabama, United States
Chandler Regional Medical Center Chandler, Az
Chandler, Arizona, United States
St. Joseph'S Hospital and Medical Center
Phoenix, Arizona, United States
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Mercy San Juan Medical Center (dignity Health)
Carmichael, California, United States
Eden Medical Center
Castro Valley, California, United States
Rancho Los Amigos National Rehabilitation Center
Downey, California, United States
Fountain Valley Regional Hospital and Medical Center
Fountain Valley, California, United States
Community Regional Medical Center
Fresno, California, United States
Ucsd Health la Jolla
La Jolla, California, United States
Sharp Grossmont Hospital
La Mesa, California, United States
Long Beach Memorial Medical Center
Long Beach, California, United States
Los Alamitos Medical Center
Los Alamitos, California, United States
Kaiser Permanente
Los Angeles, California, United States
Keck Hospital of Usc
Los Angeles, California, United States
Los Angeles County- Usc Medical Center
Los Angeles, California, United States
Ronald Reagan Ucla Medical Center
Los Angeles, California, United States
Va Greater Los Angeles - West la Va Medical Center
Los Angeles, California, United States
Uc Irvine Medical Center
Orange, California, United States
Sutter Medical Center
Sacramento, California, United States
Salinas Valley Memorial Hospital
Salinas, California, United States
Kaiser Permanent San Diego Medical Center
San Diego, California, United States
Scripps Mercy
San Diego, California, United States
Sharp Memorial Hospital
San Diego, California, United States
Ucsd Medical Center - Hillcrest Hospital
San Diego, California, United States
San Francisco General
San Francisco, California, United States
Ucsf Medical Center
San Francisco, California, United States

137 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Apixaban →Aspirin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 19 Jan 2018
Primary completion: 31 Mar 2023
Completion: 17 Apr 2023
Last update posted: 9 Apr 2025
Registered enrollment: 1,015
Registry id: NCT03192215

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.