Clinical trialNCT03205345UnknownPhase 2Interventional

Emricasan, a Caspase Inhibitor, for Treatment of Subjects With Decompensated NASH Cirrhosis

SponsorConatus Pharmaceuticals Inc.Enrollment210Decompensated Cirrhosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of emricasan in improving event-free survival based on a composite clinical endpoint (where all-cause mortality, new decompensation events, and MELD score progression are events) in subjects with decompensated NASH cirrhosis.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jean L Chan, MD
Conatus Pharmaceuticals Inc.
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

76 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

the Institute for Liver Health
Chandler, Arizona, United States
Mayo Clinic Arizona
Phoenix, Arizona, United States
St. Joseph'S Hospital & Medical Center
Phoenix, Arizona, United States
University of Arizona Liver Research Institute
Tucson, Arizona, United States
University of California, San Francisco-Fresno
Fresno, California, United States
Cedars Sinai Medical Center
Los Angeles, California, United States
Ucla Pfleger Liver Institute
Los Angeles, California, United States
California Liver Research Institute
Pasadena, California, United States
Stanford University
Redwood City, California, United States
Inland Empire Liver Foundation
Rialto, California, United States
Uc Davis Gi/hepatology Clinical Trials Unit
Sacramento, California, United States
Scripps Clinic - Torrey Pines
San Diego, California, United States
California Pacific Medical Center
San Francisco, California, United States
University of California San Francisco
San Francisco, California, United States
University of Colorado Denver
Aurora, Colorado, United States
Peak Enterology Associates
Colorado Springs, Colorado, United States
West Haven Va Medical Center
West Haven, Connecticut, United States
Uf Hepatology Research at Ctrb
Gainesville, Florida, United States
Mayo Clinic
Jacksonville, Florida, United States
Florida Research Institute
Lakewood Rch, Florida, United States
Schiff Center for Liver Disease/university of Miami
Miami, Florida, United States
Florida Hospital Transplant Institute
Orlando, Florida, United States
Imic Inc.
Palmetto Bay, Florida, United States
Tampa General Hospital
Tampa, Florida, United States
Piedmont Transplant Institute
Atlanta, Georgia, United States
Gastrointestinal Specialists of Georgia
Marietta, Georgia, United States
Northwestern University
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
Aquiant Research
Albany, Indiana, United States
Indiana University
Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics/ Internal Medicine
Iowa City, Iowa, United States
Delta Research Partners
Bastrop, Louisiana, United States
Ochsner Clinic Foundation
New Orleans, Louisiana, United States
Mercy Medical Center
Baltimore, Maryland, United States
Walter Reed National Military Medical Center (wrnmmc)
Bethesda, Maryland, United States
Digestive Disease Associates, Pa
Catonsville, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States

36 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

EmricasanPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 Jun 2017
Primary completion: 31 Aug 2019
Completion: 31 Aug 2019
Last update posted: 19 Mar 2019
Registered enrollment: 210
Registry id: NCT03205345

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.