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Clinical trialNCT03213691CompletedPhase 2Interventional

Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

SponsorNational Cancer Institute (NCI)Enrollment21Advanced Malignant Solid NeoplasmAnn Arbor Stage III Childhood Non-Hodgkin LymphomaAnn Arbor Stage IV Childhood Non-Hodgkin LymphomaRecurrent Childhood Central Nervous System NeoplasmRecurrent Childhood Non-Hodgkin LymphomaRecurrent Malignant Solid Neoplasm+5 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II Pediatric MATCH trial studies how well selumetinib sulfate works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with MAPK pathway activation mutations that have spread to other places in the body and have come back or do not respond to treatment. Selumetinib sulfate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

110 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico
  • San Jorge Children'S Hospital

    San Juan, Puerto Rico

  • University Pediatric Hospital

    San Juan, Puerto Rico

United States
  • Children'S Hospital of Alabama

    Birmingham, Alabama, United States

  • Banner Children'S at Desert

    Mesa, Arizona, United States

  • Phoenix Childrens Hospital

    Phoenix, Arizona, United States

  • Arkansas Children'S Hospital

    Little Rock, Arkansas, United States

  • Kaiser Permanente Downey Medical Center

    Downey, California, United States

  • Loma Linda University Medical Center

    Loma Linda, California, United States

  • Miller Children'S and Women'S Hospital Long Beach

    Long Beach, California, United States

  • Children'S Hospital Los Angeles

    Los Angeles, California, United States

  • Mattel Children'S Hospital Ucla

    Los Angeles, California, United States

  • Valley Children'S Hospital

    Madera, California, United States

  • Kaiser Permanente-Oakland

    Oakland, California, United States

  • Ucsf Benioff Children'S Hospital Oakland

    Oakland, California, United States

  • Lucile Packard Children'S Hospital Stanford University

    Palo Alto, California, United States

  • Ucsf Medical Center-Mission Bay

    San Francisco, California, United States

  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke'S Medical Center

    Denver, Colorado, United States

  • Yale University

    New Haven, Connecticut, United States

  • Alfred I Dupont Hospital for Children

    Wilmington, Delaware, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • University of Florida Health Science Center - Gainesville

    Gainesville, Florida, United States

  • Nemours Children'S Clinic-Jacksonville

    Jacksonville, Florida, United States

  • Nicklaus Children'S Hospital

    Miami, Florida, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, United States

  • Arnold Palmer Hospital for Children

    Orlando, Florida, United States

  • Nemours Children'S Hospital

    Orlando, Florida, United States

  • Nemours Children'S Clinic - Pensacola

    Pensacola, Florida, United States

  • Johns Hopkins All Children'S Hospital

    St. Petersburg, Florida, United States

  • Saint Joseph'S Hospital/children'S Hospital-Tampa

    Tampa, Florida, United States

  • Saint Mary'S Medical Center

    West Palm Beach, Florida, United States

  • Children'S Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, United States

  • Memorial Health University Medical Center

    Savannah, Georgia, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, United States

  • Saint Luke'S Cancer Institute - Boise

    Boise, Idaho, United States

  • Lurie Children'S Hospital-Chicago

    Chicago, Illinois, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, United States

  • Saint Jude Midwest Affiliate

    Peoria, Illinois, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, United States

  • Blank Children'S Hospital

    Des Moines, Iowa, United States

70 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Oct 2017
Primary completion
30 Jun 2021
Completion
31 Dec 2024
Last update posted
5 Feb 2025
Registered enrollment
21
Registry id
NCT03213691

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.