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Clinical trialNCT03213704Active, not recruitingPhase 2Interventional

Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

SponsorNational Cancer Institute (NCI)Enrollment9Advanced Malignant Solid NeoplasmRecurrent EpendymomaRecurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal TumorRecurrent GliomaRecurrent HepatoblastomaRecurrent Kidney Wilms Tumor+27 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II Pediatric MATCH trial studies how well larotrectinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with NTRK fusions that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and have come back (relapased) or does not respond to treatment (refractory). Larotrectinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

124 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico
  • San Jorge Children'S Hospital

    San Juan, Puerto Rico

  • University Pediatric Hospital

    San Juan, Puerto Rico

United States
  • Children'S Hospital of Alabama

    Birmingham, Alabama, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, United States

  • Banner Children'S at Desert

    Mesa, Arizona, United States

  • Banner University Medical Center - Tucson

    Tucson, Arizona, United States

  • Arkansas Children'S Hospital

    Little Rock, Arkansas, United States

  • Kaiser Permanente Downey Medical Center

    Downey, California, United States

  • Loma Linda University Medical Center

    Loma Linda, California, United States

  • Miller Children'S and Women'S Hospital Long Beach

    Long Beach, California, United States

  • Children'S Hospital Los Angeles

    Los Angeles, California, United States

  • Valley Children'S Hospital

    Madera, California, United States

  • Kaiser Permanente-Oakland

    Oakland, California, United States

  • Ucsf Benioff Children'S Hospital Oakland

    Oakland, California, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, United States

  • Ucsf Medical Center-Mission Bay

    San Francisco, California, United States

  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke'S Medical Center

    Denver, Colorado, United States

  • Yale University

    New Haven, Connecticut, United States

  • Alfred I Dupont Hospital for Children

    Wilmington, Delaware, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • Uf Health Cancer Institute - Gainesville

    Gainesville, Florida, United States

  • Nemours Children'S Clinic-Jacksonville

    Jacksonville, Florida, United States

  • Nicklaus Children'S Hospital

    Miami, Florida, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, United States

  • Adventhealth Orlando

    Orlando, Florida, United States

  • Arnold Palmer Hospital for Children

    Orlando, Florida, United States

  • Nemours Children'S Hospital

    Orlando, Florida, United States

  • Nemours Children'S Clinic - Pensacola

    Pensacola, Florida, United States

  • Johns Hopkins All Children'S Hospital

    St. Petersburg, Florida, United States

  • Saint Joseph'S Hospital/children'S Hospital-Tampa

    Tampa, Florida, United States

  • Saint Mary'S Medical Center

    West Palm Beach, Florida, United States

  • Children'S Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, United States

  • Saint Luke'S Cancer Institute - Boise

    Boise, Idaho, United States

  • Lurie Children'S Hospital-Chicago

    Chicago, Illinois, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, United States

  • Osf Children'S Hospital of Illinois

    Peoria, Illinois, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, United States

  • Ascension Saint Vincent Indianapolis Hospital

    Indianapolis, Indiana, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, United States

84 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
23 Aug 2017
Primary completion
30 Sept 2024
Completion
8 Oct 2026
Last update posted
17 Jun 2026
Registered enrollment
9
Registry id
NCT03213704

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.