FindMyKOL
Clinical trialNCT03217266CompletedPhase 1Interventional

Navtemadlin and Radiation Therapy in Treating Patients With Soft Tissue Sarcoma

SponsorNational Cancer Institute (NCI)Enrollment39Resectable Soft Tissue SarcomaSoft Tissue Sarcoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase Ib trial studies the side effects of navtemadlin and radiation therapy in treating patients with soft tissue sarcoma. Navtemadlin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving navtemadlin and radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

53 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Ctca at Western Regional Medical Center

    Goodyear, Arizona, United States

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona, United States

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, United States

  • University of Arizona Cancer Center-North Campus

    Tucson, Arizona, United States

  • University of Arizona Cancer Center-Orange Grove Campus

    Tucson, Arizona, United States

  • Uchealth University of Colorado Hospital

    Aurora, Colorado, United States

  • Poudre Valley Hospital

    Fort Collins, Colorado, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, United States

  • Emory University Hospital/winship Cancer Institute

    Atlanta, Georgia, United States

  • Northside Hospital

    Atlanta, Georgia, United States

  • Ctca at Southeastern Regional Medical Center

    Newnan, Georgia, United States

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, United States

  • Northwestern University

    Chicago, Illinois, United States

  • Rush University Medical Center

    Chicago, Illinois, United States

  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas, United States

  • the James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, United States

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, United States

  • Siteman Cancer Center-South County

    St Louis, Missouri, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Benefis Sletten Cancer Institute

    Great Falls, Montana, United States

  • Logan Health Medical Center

    Kalispell, Montana, United States

  • Nebraska Methodist Hospital

    Omaha, Nebraska, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, United States

  • Nyp/columbia University Medical Center/herbert Irving Comprehensive Cancer Center

    New York, New York, United States

  • Unc Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, United States

  • Eastern Regional Medical Center

    Philadelphia, Pennsylvania, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, United States

  • Upmc-Shadyside Hospital

    Pittsburgh, Pennsylvania, United States

  • Parkland Memorial Hospital

    Dallas, Texas, United States

  • Ut Southwestern/simmons Cancer Center-Dallas

    Dallas, Texas, United States

  • Aurora Cancer Care-Southern Lakes Vlcc

    Burlington, Wisconsin, United States

  • Aurora Health Center-Fond Du Lac

    Fond du Lac, Wisconsin, United States

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin, United States

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin, United States

  • Aurora Baycare Medical Center

    Green Bay, Wisconsin, United States

13 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Navtemadlin
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
20 Jun 2018
Primary completion
27 Aug 2023
Completion
4 Sept 2025
Last update posted
23 Sept 2025
Registered enrollment
39
Registry id
NCT03217266

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.