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Clinical trialNCT03225924TerminatedPhase 1/PHASE2Interventional

Study of Entospletinib (ENTO) in Newly Diagnosed DLBCL Patients With aaIPI>=1 Treated by Chemiotherapy

SponsorThe Lymphoma Academic Research OrganisationEnrollment25DLBCL
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary objective of the phase Ib of the study is to determine the recommended phase 2 dose (RP2D) for entospletinib (ENTO) in patients treated with R-CHOP. The primary objective of the phase II is to determine the complete metabolic response (CMR) rate by the Lugano classification 2014 (Deauville scale 1-3) at the end of treatment.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

27 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Belgium
  • Clinique Universite Catholique de Louvain Saint-Luc

    Brussels, Belgium

  • Institut Jules Bordet

    Brussels, Belgium

  • University Hospital Gent

    Ghent, Belgium

  • Hopital Joliment

    Haine-Saint-Paul, Belgium

  • Az Groeninge

    Kortrijk, Belgium

  • Ucl Namur

    Yvoir, Belgium

France
  • Ch de Bourg En Bresse

    Bourg-en-Bresse, France

  • Chu Côte de Nacre

    Caen, France

  • Chu Henri Mondor

    Créteil, France

  • Chu de Dijon

    Dijon, France

  • Ch de Versailles - Hopital Andre Mignot

    Le Chesnay, France

  • Clinique Victor Hugo

    Le Mans, France

  • Chu de Limoges - Hopital Dupuytren

    Limoges, France

  • Chu Lyon Sud

    Lyon, France

  • Clinique de la Sauvegarde

    Lyon, France

  • Chu Montpellier

    Montpellier, France

  • Ch Region Mulhouse Et Sud Alsace

    Mulhouse, France

  • Hopital Necker Paris

    Paris, France

  • Chu de Bordeaux

    Pessac, France

  • Ch Annecy Genevois

    Pringy, France

  • Chu de Reims - Hopital Robert Debre

    Reims, France

  • Chu de Rennes - Pontchaillou

    Rennes, France

  • Ch de Roubaix-Hopital Victor Provo

    Roubaix, France

  • Iuct Oncopole de Toulouse

    Toulouse, France

  • Hôpital Bretonneau- Centre H. Kaplan

    Tours, France

  • Ch de Valenciennes

    Valenciennes, France

  • Chru de Nancy

    Vandœuvre-lès-Nancy, France

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
26 Jul 2017
Primary completion
18 Oct 2019
Completion
18 Oct 2019
Last update posted
2 Sept 2020
Registered enrollment
25
Registry id
NCT03225924

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.