Clinical trialNCT03227679CompletedInterventional

Metabolism-informed Care for Smoking Cessation

SponsorVanderbilt University Medical CenterEnrollment82Tobacco UseTobacco Use Cessation

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Nicotine mediates smoking's addictive effects in the brain. The ratio of 3-hydroxycotinine to cotinine, known as the nicotine metabolite ratio, or NMR, is a genetically- informed biomarker reflecting hepatic CYP2A6 activity and the rate of nicotine metabolism. In light of a recent randomized controlled trial (RCT) in humans in Lancet Respiratory Medicine, which found that the NMR can be used to individualize treatment for smokers, our pilot study aims to determine the feasibility of using NMR to guide selection of pharmacotherapy in clinical populations of daily smokers.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Dawn Beaulieu, MD
Vanderbilt University Medical Center
Principal Investigator
clinicaltrials.gov ↗
Hilary Tindle, MD
Vanderbilt University Medical Center
Principal Investigator
clinicaltrials.gov ↗
Matthew Freiberg, MD
Vanderbilt University Medical Center
Principal Investigator
clinicaltrials.gov ↗
Quinn Wells, MD
Vanderbilt University Medical Center
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

No facility list is in our current data snapshot for this study. The registry record on ClinicalTrials.gov ↗ carries any published locations. Why? →

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bupropion →Nicotine patchVarenicline →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 18 May 2016
Primary completion: 8 Oct 2016
Completion: 18 Apr 2017
Last update posted: 6 Jan 2026
Registered enrollment: 82
Registry id: NCT03227679

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.