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Clinical trialNCT03238495UnknownPhase 2Interventional

Randomized Trial of Neo-adjuvant Chemotherapy With or Without Metformin for HER2 Positive Operable Breast Cancer

SponsorQamar KhanEnrollment100HER2-positive Breast Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary objective of this study is to determine the efficacy of metformin as a repurposed agent in human epidermal growth factor receptor 2 (HER2) positive breast cancer when added to standard neo-adjuvant chemotherapy.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • the University of Kansas Cancer Center, West Clinic

    Kansas City, Kansas, United States

    Recruiting
  • the University of Kansas Cancer Center, Westwood Campus

    Kansas City, Kansas, United States

    Recruiting
  • the University of Kansas Cancer Center, Overland Park Clinic

    Overland Park, Kansas, United States

    Recruiting
  • the University of Kansas Cancer Center, North Clinic

    Kansas City, Missouri, United States

    Recruiting
  • the University of Kansas Cancer Center, South Clinic

    Kansas City, Missouri, United States

    Recruiting
  • the University of Kansas Cancer Center, Lee'S Summit Clinic

    Lee's Summit, Missouri, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Metformin →Taxotere, Carboplatin, Herceptin + Pertuzumab
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
15 Aug 2017
Primary completion
1 Jun 2022
Completion
1 Jun 2023
Last update posted
7 Dec 2021
Registered enrollment
100
Registry id
NCT03238495
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.