Clinical trialNCT03257462CompletedPhase 2Interventional

Study of SPR001 in Adults With Classic Congenital Adrenal Hyperplasia

SponsorSpruce BiosciencesEnrollment24CAH - Congenital Adrenal HyperplasiaCongenital Adrenal Hyperplasia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multicenter Phase 2, multiple dose, dose escalation study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of SPR001 in adult patients with classic congenital adrenal hyperplasia (CAH).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Richard Auchus, MD, PhD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
Spruce Chief Medical Officer, MD
Spruce Biosciences
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Spruce Biosciences Clinical Site
Orange, California, United States
Spruce Biosciences Clinical Site
San Diego, California, United States
Spruce Biosciences Clinical Site
Melbourne, Florida, United States
Spruce Biosciences Clinical Site
Atlanta, Georgia, United States
Spruce Biosciences Clinical Site
Indianapolis, Indiana, United States
Spruce Biosciences Clinical Site
Ann Arbor, Michigan, United States
Spruce Biosciences Clinical Site
Minneapolis, Minnesota, United States
Spruce Biosciences Clinical Site
Las Vegas, Nevada, United States
Spruce Biosciences Clinical Site
Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

SPR001

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 12 Jul 2017
Primary completion: 2 Mar 2019
Completion: 29 Mar 2019
Last update posted: 22 Oct 2025
Registered enrollment: 24
Registry id: NCT03257462

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.