Clinical trialNCT03263117CompletedPhase 4Interventional

SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke

SponsorThe University of Texas Health Science Center, HoustonEnrollment260Stroke

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Objectives: This study aims to estimate overall treatment benefit (improvement in disability) among acute ischemic stroke patients that are randomized to General Anesthesia (GA) compared with Sedation (CS) during endovascular therapy. Assess safety (as measured by incidence of symptomatic intracranial hemorrhage); rates of Endovascular therapy (EVT) procedural complications, reperfusion; and quality of life. Hypothesis: GA during EVT for acute ischemic stroke improves functional outcomes at 90 days compared to sedation.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Andrew Barreto, MD
The University of Texas Health Science Center, Houston
Principal Investigator
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Carlos Artime, MD
The University of Texas Health Science Center, Houston
Principal Investigator
clinicaltrials.gov ↗
Claudia Pedroza, PhD
The University of Texas Health Science Center, Houston
Principal Investigator
clinicaltrials.gov ↗
Peng Roc Chen, MD
The University of Texas Health Science Center, Houston
Study Chair
clinicaltrials.gov ↗
Sean Savitz, MD
The University of Texas Health Science Center, Houston
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Sunil Sheth, MD
The University of Texas Health Science Center, Houston
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

11 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Indiana University College of Medicine
Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Henry Ford Health System
Louisville, Kentucky, United States
Rochester Regional Health
Rochester, New York, United States
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States
Geisinger Health
Danville, Pennsylvania, United States
Temple University
Philadelphia, Pennsylvania, United States
Baylor College of Medicine
Houston, Texas, United States
Memorial Hermann Hospital System - Memorial City Medical Center
Houston, Texas, United States
University of Texas Health Science Center Houston With Memorial Hermann Hospital System - the Medical Center
Houston, Texas, United States
Memorial Hermann Hospital System - the Woodlands Medical Center
The Woodlands, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

General AnesthesiaSedation

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Jul 2018
Primary completion: 22 Apr 2023
Completion: 22 Apr 2023
Last update posted: 26 Nov 2025
Registered enrollment: 260
Registry id: NCT03263117

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.