Clinical trialNCT03304756CompletedPhase 2Interventional

Study of Neoadjuvant Treatment of Locally Advanced Breast Cancer With CAP Regimen

SponsorInstituto Nacional de Cancer, BrazilEnrollment41Triple Negative Breast Cancer Patients

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a single arm, single center, non-randomized, phase II trial of stage IIB/III TNBC. Patients received neoadjuvant chemotherapy with cisplatin (50 mg/m2) in combination with doxorubicin (50 mg/m2) and cyclophosphamide (500 mg/m2) every 21 days and for a total of 6 cycles. After surgery, adjuvant chemotherapy consisting of docetaxel (75 mg/m2) every 21 days was further provided for 4 cycles. Primary outcome was pathological complete response in the breast and axilla (pCR; ypT0ypN0). Secondary outcomes were safety, disease-free survival and overall survival.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

José Bines, Doctorate
Instituto Nacional de Cancer
Study Chair
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José Bines, Doctorate
Instituto Nacional de Cancer
Principal Investigator
clinicaltrials.gov ↗
Otto Metzger, Oncologist
Medical oncologist in Boston, and affiliated with Dana-Farber Cancer Institute
Study Director
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

No facility list is in our current data snapshot for this study. The registry record on ClinicalTrials.gov ↗ carries any published locations. Why? →

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CAP

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 15 Dec 2007
Primary completion: 15 Apr 2012
Completion: 15 Dec 2014
Last update posted: 25 Oct 2017
Registered enrollment: 41
Registry id: NCT03304756

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.