Clinical trialNCT03332095CompletedPhase 1/PHASE2Interventional

Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (MK-1439A) in HIV-1-Infected Children and Adolescents

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment55HIV Infections

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study was to evaluate the pharmacokinetics, safety, and tolerability of doravirine (also called MK-1439 or DOR) and doravirine/lamivudine/tenofovir disoproxil fumarate (also called MK-1439A or DOR/3TC/TDF) in HIV-1-infected children and adolescents.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Ann Melvin, MD, MPH
University of Washington, Seattle Children's Research Institute
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Africa

Soweto Impaact Crs
Johannesburg, Gauteng, South Africa

Thailand

Siriraj Hospital ,mahidol University Nichd Crs
Bangkok, Bangkoknoi, Thailand
Chiang Mai University Hiv Treatment (cmu Hiv Treatment) Crs
Chiang Mai, Thailand
Chiangrai Prachanukroh Hospital Nichd Crs
Chiang Mai, Thailand

United States

Univ. of Colorado Denver Nichd Crs
Aurora, Colorado, United States
Boston Medical Center Ped. Hiv Program Nichd Crs
Boston, Massachusetts, United States
St. Jude Children'S Research Hospital Crs
Memphis, Tennessee, United States
Seattle Children'S Research Institute Crs
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Antiretroviral medicationsDoravirine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 2 Jul 2018
Primary completion: 19 Aug 2020
Completion: 25 May 2022
Last update posted: 14 Feb 2023
Registered enrollment: 55
Registry id: NCT03332095

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.